کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1370034 | 981802 | 2016 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Synthesis, biological evaluation and molecular docking studies of 2-piperazin-1-yl-quinazolines as platelet aggregation inhibitors and ligands of integrin αIIbβ3
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Synthesis, biological evaluation and molecular docking studies of 2-piperazin-1-yl-quinazolines as platelet aggregation inhibitors and ligands of integrin αIIbβ3 Synthesis, biological evaluation and molecular docking studies of 2-piperazin-1-yl-quinazolines as platelet aggregation inhibitors and ligands of integrin αIIbβ3](/preview/png/1370034.png)
چکیده انگلیسی
A series of 2-piperazin-1-yl-quinazolines were synthesized and evaluated for their antiaggregative activity. The synthesized small molecule compounds have potently inhibited platelet aggregation in vitro and blocked FITC-Fg binding to αIIbβ3 integrin in a suspension of washed human platelets. The key αIIbβ3 protein–ligand interactions were determined in docking experiments and some correlations have been observed between values of the affinity and docking scores.
This work reports the synthesis and biological activity of 2-piperazin-1-yl-quinazolines. Molecular docking of ligand–αIIbβ3 complexes showed the key interactions.Figure optionsDownload as PowerPoint slide
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 26, Issue 7, 1 April 2016, Pages 1839–1843
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 26, Issue 7, 1 April 2016, Pages 1839–1843
نویسندگان
Andrei A. Krysko, Alexander Yu. Kornylov, Pavel G. Polishchuk, Georgiy V. Samoylenko, Olga L. Krysko, Tatyana A. Kabanova, Victor Ch. Kravtsov, Vladimir M. Kabanov, Barbara Wicher, Sergei A. Andronati,