کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1370145 | 981809 | 2011 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Design and synthesis of pyridone inhibitors of non-nucleoside reverse transcriptase
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
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چکیده انگلیسی
Next generation NNRTIs are sought which possess both broad spectrum antiviral activity against key mutant strains and a high genetic barrier to the selection of new mutant viral strains. Pyridones were evaluated as an acyclic conformational constraint to replace the aryl ether core of MK-4965 (1) and the more rigid indazole constraint of MK-6186 (2). The resulting pyridone compounds are potent inhibitors of HIV RT and have antiviral activity in cell culture that is superior to other next generation NNRTI’s.
Pyridone inhibitors of non-nucleoside reverse transcriptase (NNRTI) with improved potency are reported.Figure optionsDownload as PowerPoint slide
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 21, Issue 24, 15 December 2011, Pages 7344–7350
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 21, Issue 24, 15 December 2011, Pages 7344–7350
نویسندگان
Robert Gomez, Samson Jolly, Theresa Williams, Thomas Tucker, Robert Tynebor, Joe Vacca, Georgia McGaughey, Ming-Tain Lai, Peter Felock, Vandna Munshi, Daniel DeStefano, Sinoeun Touch, Mike Miller, Youwei Yan, Rosa Sanchez, Yuexia Liang, Brenda Paton,