کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1370163 981809 2011 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Diabetic nephropathy-related active cyclic peptides from the roots of Brachystemma calycinum
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Diabetic nephropathy-related active cyclic peptides from the roots of Brachystemma calycinum
چکیده انگلیسی

Three new cyclic peptides, namely duanbanhuains A–C (1–3), were isolated from the roots of Brachystemma calycinum which is a traditional medicine used to treat rheumatic diseases. Their structures were identified by means of a suite of MS and NMR experiments. These compounds were purposely evaluated for their inhibitory effects on the release of MCP-1, IL-6, collagen IV and reactive oxygen species (ROS) against high-glucose-stimulated mesangial cells. The results showed that compounds 1 and 2 exhibited potent inhibition on the production of IL-6, collagen IV and ROS at the concentration of 10 μM.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 21, Issue 24, 15 December 2011, Pages 7434–7439
نویسندگان
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