کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1370253 981814 2011 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Discovery of a new class of glucosylceramide synthase inhibitors
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Discovery of a new class of glucosylceramide synthase inhibitors
چکیده انگلیسی

A novel series of potent inhibitors of glucosylceramide synthase are described. The optimization of biochemical and cellular potency as well as ADME properties led to compound 23c. Broad tissue distribution was obtained following oral administration to mice. Thus 23c could be another useful tool compound for studying the effects of GCS inhibition in vitro and in vivo.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 21, Issue 22, 15 November 2011, Pages 6773–6777
نویسندگان
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