Synthesis of purine modified 2′-C-methyl nucleosides as potential anti-HCV agents

Based on the anti-hepatitis C activity of 2′-C-methyl-adenosine and 2′-C-methyl-guanosine, a series of new modified purine 2′-C-methyl nucleosides was prepared as potential anti-hepatitis C virus agents. Herein, we report the synthesis of both 6-modified and 2-modified purine 2′-C-methyl-nucleosides along with their anti-HCV replication activity and cytotoxicity in different cells.

A series of new purine modified 2′-C-methyl nucleosides was prepared and evaluated as potential anti-hepatitis C virus agents.Figure optionsDownload as PowerPoint slide