کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1370628 981823 2011 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Osteogenic constituents from Pterospermum acerifolium Willd. flowers
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Osteogenic constituents from Pterospermum acerifolium Willd. flowers
چکیده انگلیسی

Phytochemical investigation of ethanol extracts of the Pterospermumacerifolium flowers led to the isolation and identification of two new flavones, 4′-(2-methoxy-4-(1,2,3-trihydroxypropyl) phenoxy luteolin (1) and 5,7,3′-trihydroxy-6-O-β-d-glucopyranosyl flavone (2), and one new lactone, 3,5-dihydroxyfuran-2(5H)-one (3) along with 14 known compounds (4–17). The structure of compounds 1–17 was established based on MS, 1D and 2D NMR, spectroscopic analysis. Eight of these compounds (1–6, 8 and 9) were assessed for osteogenic activity by using primary cultures of rat osteoblast. The compounds 1, 3 and 4 significantly stimulated osteoblast differentiation and mineralization as evident from a marked increase in expression of alkaline phosphatase and alizarin red-S staining of osteoblasts.

Three new compounds pterospermin A (1), pterospermin B (2) and pterospermin C (3) along with 14 known compounds (4–17) were isolated from the Pterospermum acerifolium. Compounds 1, 3 and 4 showed significant osteogenic activity.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 21, Issue 15, 1 August 2011, Pages 4617–4621
نویسندگان
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