کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1370670 | 981824 | 2011 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Benzotriazinone and benzopyrimidinone derivatives as potent positive allosteric AMPA receptor modulators
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
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چکیده انگلیسی
AMPA receptors (AMPARs) have been demonstrated to be an important therapeutic CNS target. A series of substituted benzotriazinone and benzopyrimidinone derivatives were prepared with the aim to improve in vivo activity over the previously reported bis-benzoxazinone based AMPAKINE® series from our laboratory. These compounds were shown to be potent, positive allosteric AMPAR modulators that have better in vivo activity and improved metabolic stability over the analogous benzoxazinone derivatives.
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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 21, Issue 20, 15 October 2011, Pages 6170–6175
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 21, Issue 20, 15 October 2011, Pages 6170–6175
نویسندگان
Rudolf Mueller, Stanislaw Rachwal, Steven Lee, Sheng Zhong, Yong-Xin Li, Peter Haroldsen, Todd Herbst, Susan Tanimura, Mark Varney, Steven Johnson, Gary Rogers, Leslie J. Street,