کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1370719 981827 2015 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Structure–activity relationship study of E6 as a novel necroptosis inducer
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Structure–activity relationship study of E6 as a novel necroptosis inducer
چکیده انگلیسی

Necroptosis inducers represent a promising potential treatment for drug-resistant cancer. We herein describe the structure modification of E6, which was identified recently as a potent and selective necroptosis inducer. The studies described herein demonstrate for the first time that functionalized biphenyl derivatives possess necroptosis inducer activity. Furthermore, these studies have led to the identification of two promising compounds (5h and 5j) that can be used for further optimization studies as well as mechanism of action investigations.

The structure modification of E6, which was identified recently as a potent and selective necroptosis inducer led to the identification of two promising compounds (5h and 5j) that can be used for further optimization studies as well as mechanism of action investigations.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 25, Issue 15, 1 August 2015, Pages 3057–3061
نویسندگان
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