کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1370728 | 981828 | 2011 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
2,3-Substituted quinoxalin-6-amine analogs as antiproliferatives: A structure–activity relationship study
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: 2,3-Substituted quinoxalin-6-amine analogs as antiproliferatives: A structure–activity relationship study 2,3-Substituted quinoxalin-6-amine analogs as antiproliferatives: A structure–activity relationship study](/preview/png/1370728.png)
چکیده انگلیسی
The quinoxaline core is considered a privileged scaffold as it is found in a variety of biologically relevant molecules. Here we report the synthesis of a quinoxalin-6-amine library, screening against a panel of cancer cell lines and a structure–activity relationship (SAR). This resulted in the identification of a bisfuranylquinoxalineurea analog (7c) that has low micromolar potency against the panel of cancer cell lines. We also show that cells treated with quinoxalineurea 7c results in caspase 3/7 activation, PARP cleavage and Mcl-1 dependent apoptosis.
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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 21, Issue 7, 1 April 2011, Pages 1929–1932
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 21, Issue 7, 1 April 2011, Pages 1929–1932
نویسندگان
Qianyi Chen, Vashti C. Bryant, Hernando Lopez, David L. Kelly, Xu Luo, Amarnath Natarajan,