کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1370757 981828 2011 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Novel analogues of ketamine and phencyclidine as NMDA receptor antagonists
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Novel analogues of ketamine and phencyclidine as NMDA receptor antagonists
چکیده انگلیسی

The identification of structurally novel analogues of ketamine and phencyclidine (PCP), as NMDA receptor antagonists, with low to moderate potency at GluN2A and GluN2B receptors is discussed. In particular, some examples, such as compounds 6 and 10, shows decreased calculated lipophilicity, when compared to PCP, while retaining moderate activity. Moreover, the germinal aryl amino substituted lactam ring, as exemplified in compounds 7–10 and 11–13, constitutes a novel scaffold with potential application in the design of biologically active compounds.

The identification of structurally novel analogues of ketamine and phencyclidine (PCP), as NMDA receptor antagonists, with low to moderate potency at GluN2A and GluN2B receptors is discussed. In particular, some examples, such as compounds 6 and 10, show decreased calculated lipophilicity, when compared to PCP, while retaining moderate activity. Moreover, the germinal aryl amino substituted lactam ring, as exemplified in compounds 7–10 and 11–13, constitutes a novel scaffold with potential application in the design of biologically active compounds.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 21, Issue 7, 1 April 2011, Pages 2059–2063
نویسندگان
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