کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1370784 | 981830 | 2011 | 4 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: αvβ3-Integrin-targeting lanthanide complex: Synthesis and evaluation as a tumor-homing luminescent probe αvβ3-Integrin-targeting lanthanide complex: Synthesis and evaluation as a tumor-homing luminescent probe](/preview/png/1370784.png)
The application of lanthanide complexes in the time-resolved fluorescence imaging of living cells has emerged in the last few decades, providing high-contrast images of cells through detection of the delayed emission. In the present study, we synthesized novel trivalent lanthanide complexes containing the cyclic peptide c(RGDfK) to visualize the αvβ3-integrin-expressing tumor cells. Conjugation of c(RGDfK) with the macrocyclic bipyridine ligand had little effect on the fluorescence properties of the complex, indicating that the coordinated lanthanide ion was well isolated from the peptide. Bright luminescence images of αvβ3-integrin-expressing U87-MG cells were successfully obtained by employing the probes.
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Journal: Bioorganic & Medicinal Chemistry Letters - Volume 21, Issue 12, 15 June 2011, Pages 3515–3518