کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1370795 | 981830 | 2011 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Novel, potent, and orally bioavailable phosphinic acid inhibitors of the hepatitis C virus NS3 protease
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
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چکیده انگلیسی
A potent and novel class of product-like inhibitors of the HCV NS3 protease was discovered by employing a phosphinic acid as a carboxylate isostere. The replicon activity and pharmacokinetic profile of this series of compounds was optimized by exploring the substitution of the phosphinic acid, as well as conformationally constraining these compounds through macrocyclization. The syntheses and preliminary biological evaluation of these phosphinic acids is described.
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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 21, Issue 12, 15 June 2011, Pages 3568–3572
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 21, Issue 12, 15 June 2011, Pages 3568–3572
نویسندگان
Michael O. Clarke, Xiaowu Chen, Aesop Cho, William E. Delaney IV, Edward Doerffler, Maria Fardis, Mingzhe Ji, Michael Mertzman, Rowchanak Pakdaman, Hyun-Jun Pyun, Tanisha Rowe, Cheng Y. Yang, X. Christopher Sheng, Choung U. Kim,