کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1370937 981833 2011 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis and DNA photocleavage by a pyridine-linked bis-acridine chromophore in the presence of copper(II): Ionic strength effects
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Synthesis and DNA photocleavage by a pyridine-linked bis-acridine chromophore in the presence of copper(II): Ionic strength effects
چکیده انگلیسی

We report the synthesis of photonuclease 3 consisting of two acridine rings joined by a 2,6-bis(aminomethyl)pyridine copper-binding linker. In reactions containing micromolar concentrations of 3, irradiation at 419 nm produces efficient, copper(II)-dependent cleavage of plasmid DNA in the presence of the high concentrations of salt that exist in the cell nucleus (150 mM NaCl and 260 mM KCl). The DNA interactions of 3 are compared to an analogous bis-acridine (4) containing a more flexible 2,6-bis{[(methoxycarbonylamino)-ethyl]methylaminomethyl}pyridine unit.

Copper(II) chloride enhances DNA photocleavage by bis-acridine 3 in the presence of physiological concentrations of salt.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 21, Issue 3, 1 February 2011, Pages 1047–1051
نویسندگان
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