کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1371005 | 981834 | 2011 | 5 صفحه PDF | دانلود رایگان |
A new iridoid, named methylscutelloside (1) together with 19 known compounds belonging to the iridoids (2–4), monoterpenoids (5), flavonoids (6–8), triterpenoids (9–14), and phenylethanoids (15–20) were isolated from the flowers of Buddleja officinalis. Their chemical structures were elucidated on the basis of physicochemical properties, and by spectroscopic methods including 1D, 2D NMR, and MS. All isolated compounds were tested in vitro for their effects on the proliferation of rat aortic vascular smooth muscle cells (VSMCs). Among them, iridoids were the main active components and showed significant inhibitory effects on PDGF-BB-induced proliferation in rat aortic VSMCs.
A new iridoid, named methylscutelloside (1) together with 19 known compounds belonging to the iridoids (2–4), monoterpenoids (5), flavonoids (6–8), triterpenoids (9–14), and phenylethanoids (15–20) were isolated from the flowers of Buddleja officinalis. Their chemical structures were elucidated on the basis of physicochemical properties, and by spectroscopic methods including 1D, 2D NMR, and MS. All isolated compounds were tested in vitro for their effects on the proliferation of rat aortic vascular smooth muscle cells (VSMCs). Among them, iridoids were the main active components and showed significant inhibitory effects on PDGF-BB-induced proliferation in rat aortic VSMCs.Figure optionsDownload as PowerPoint slide
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 21, Issue 11, 1 June 2011, Pages 3462–3466