کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1371032 981837 2015 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Glycyrrhizic acid derivatives as influenza A/H1N1 virus inhibitors
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Glycyrrhizic acid derivatives as influenza A/H1N1 virus inhibitors
چکیده انگلیسی

This Letter describes the synthesis and antiviral activity study of some glycyrrhizic acid (GL) derivatives against influenza A/H1N1/pdm09 virus in MDCK cells. Conjugation of GL with l-amino acids or their methyl esters, and amino sugar (d-galactose amine) dramatically changed its activity. The most active compounds were GL conjugates with aromatic amino acids methyl esters (phenylalanine and tyrosine) (SI = 61 and 38), and S-benzyl-cysteine (SI = 71). Thus modification of GL is a perspective route in the search of new antivirals, and some of GL derivatives are potent as anti-influenza A/H1N1 agents.

Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 25, Issue 8, 15 April 2015, Pages 1742–1746
نویسندگان
, , , , , , ,