کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1371083 | 981838 | 2011 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Replacement of the double bond of antitubulin chalcones with triazoles and tetrazoles: Synthesis and biological evaluation
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Replacement of the double bond of antitubulin chalcones with triazoles and tetrazoles: Synthesis and biological evaluation Replacement of the double bond of antitubulin chalcones with triazoles and tetrazoles: Synthesis and biological evaluation](/preview/png/1371083.png)
چکیده انگلیسی
In the chalcone scaffold, it is thought that the double bond is an important structural linker but it is likely not essential for the interaction with tubulin. Yet, it may be a potential site of metabolic degradation and interaction with biological nucleophiles. In this letter, we have replaced this olefinic portion of chalcones with two metabolically stable and chemically inert heterocyclic rings, namely triazole or tetrazole. Yet, our biologic data suggest that, unlike in other antitubulinic structures, the olephinic ring might not be merely a structural linker.
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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 21, Issue 2, 15 January 2011, Pages 764–768
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 21, Issue 2, 15 January 2011, Pages 764–768
نویسندگان
Ornella Mesenzani, Alberto Massarotti, Mariateresa Giustiniano, Tracey Pirali, Valentina Bevilacqua, Antonio Caldarelli, Pierluigi Canonico, Giovanni Sorba, Ettore Novellino, Armando A. Genazzani, Gian Cesare Tron,