Potent inhibitors of hepatitis C core dimerization as new leads for anti-hepatitis C agents

New indoline alkaloid-type compounds which inhibit HCV production by infected hepatoma cells have been identified. These compounds, dimeric-type compounds of previously known inhibitors, display double digit nanomolar IC50 and EC50 values, with cytotoxicity CC50 indexes higher than 36 μM, thus providing ample therapeutic windows for further development of HCV drugs.

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