کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1371145 981839 2011 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
One-pot synthesis and anticancer studies of 2-arylamino-5-aryl-1,3,4-thiadiazoles
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
One-pot synthesis and anticancer studies of 2-arylamino-5-aryl-1,3,4-thiadiazoles
چکیده انگلیسی

A series of 2-arylamino-5-aryl-1,3,4-thiadiazoles 1a–j were synthesized and screened for their anticancer activity against various human cancer cell lines. The novel one-pot synthesis of 1,3,4-thiadiazoles was achieved by refluxing aryl aldehydes, hydrazine hydrate, and aryl isothiocyanates in methanol followed by oxidative cyclization with ferric ammonium sulfate. The compounds 1g–j with trimethoxyphenyl at the C-5 position displayed extremely potent anticancer activity with at least twofold selectivity (IC50: 4.3–9.2 μM). The nature of substituent on the C-2 arylamino ring may be critical in opting for the selectivity towards a particular cancer cell.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 21, Issue 8, 15 April 2011, Pages 2320–2323
نویسندگان
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