کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1371268 | 981841 | 2012 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Design and synthesis of polyethylene glycol-modified biphenylsulfonyl-thiophene-carboxamidine inhibitors of the complement component C1s
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Complement C1s protease inhibitors have potential utility in the treatment of diseases associated with activation of the classical complement pathway such as humorally mediated graft rejection, ischemia-reperfusion injury (IRI), vascular leak syndrome, and acute respiratory distress syndrome (ARDS). The utility of biphenylsulfonyl-thiophene-carboxamidine small-molecule C1s inhibitors are limited by their poor in vivo pharmacokinetic properties. Pegylation of a potent analog has provided compounds with good potency and good in vivo pharmacokinetic properties.
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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 22, Issue 16, 15 August 2012, Pages 5303–5307
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 22, Issue 16, 15 August 2012, Pages 5303–5307
نویسندگان
Nalin L. Subasinghe, Ehab Khalil, Jeremy M. Travins, Farah Ali, Shelley K. Ballentine, Heather R. Hufnagel, Wenxi Pan, Kristi Leonard, Roger F. Bone, Richard M. Soll, Carl S. Crysler, Nisha Ninan, Jennifer Kirkpatrick, Michael X. Kolpak,