کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1371419 981845 2011 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Biotin tethered homotryptamine derivatives: High affinity probes of the human serotonin transporter (hSERT)
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Biotin tethered homotryptamine derivatives: High affinity probes of the human serotonin transporter (hSERT)
چکیده انگلیسی

Quantum dot conjugates of compounds capable of inhibiting the serotonin transporter (SERT) could form the basis of fluorescent probes for live cell imaging of membrane bound SERT. Additionally, quantum dot-SERT antagonist conjugates may be amenable to fluorescence-based, high-throughput assays for this transporter. This Letter describes the synthesis of SERT-selective ligands amenable to conjugation to quantum dots via a biotin–streptavidin binding interaction. SERT selectivity and affinity were incorporated into the ligand via a tetrahydropyridine or cyclohexylamine derivative and the affinity of these compounds for SERT was measured by their ability to produce SERT-dependent currents in Xenopus laveis oocytes.

Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 21, Issue 6, 15 March 2011, Pages 1678–1682
نویسندگان
, , , ,