Quinolizidinone carboxylic acid selective M1 allosteric modulators: SAR in the piperidine series

SAR study of the piperidine moiety in a series of quinolizidinone carboxylic acid M1 positive allosteric modulators was examined. While the SAR was generally flat, compounds were identified with high CNS exposure to warrant additional in vivo evaluation.

SAR study of the piperidine moiety in a series of quinolizidinone carboxylic acid M1 positive allosteric modulators was examined.Figure optionsDownload as PowerPoint slide