Novel dihydrothieno[2,3-e]indazole derivatives as IκB kinase inhibitors

Synthesis, and structure–activity relationship (SAR) studies of the novel IKK-β inhibitors 2 and 3 characterized by a dihydrothieno[2,3-e]indazole core are presented. Compound 2t was efficacious in a mouse model of LPS-stimulated TNF-α production.

IKK-β inhibitors characterized by a dihydrothieno [2,3-e] indazole core are reported. Compound 2t was efficacious in a mouse model of LPS-stimulated TNF-α production.Figure optionsDownload as PowerPoint slide