کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1371438 981845 2011 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Design, synthesis and in vitro cytotoxicity of novel dinuclear platinum(II) complexes
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Design, synthesis and in vitro cytotoxicity of novel dinuclear platinum(II) complexes
چکیده انگلیسی

Five dinuclear platinum(II) complexes with a novel chiral ligand, 2-(((1R,2R)-2-aminocyclohexylamino)methyl)phenol (HL), were designed, prepared and spectrally characterized. In vitro cytotoxicity of all the resulting platinum(II) compounds was evaluated against human HEPG-2, A549 and HCT-116 cell lines, respectively. Results indicated that all compounds showed positive biological activity. Particularly, compound D4 has lower IC50 values than carboplatin toward HEPG-2 and A549, while compound D5 shows better activity than carboplatin against A549.

Novel dinuclear platinum(II) complexes were designed, prepared and biologically evaluated. Results indicated that compound D4 showed better antitumor activity than carboplatin against two selected human cell lines.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 21, Issue 6, 15 March 2011, Pages 1763–1766
نویسندگان
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