Synthesis and biological evaluation of [d-lysine]8cyclosporin A analogs as potential anti-HCV agents

An efficient synthesis of [d-lysine]8cyclosporin A has been developed. Several analogs of [d-lysine]8cyclosporin A have been synthesized and show promising anti-HCV activity, particularly compounds 39 and 43, which each exhibit an anti-HCV EC50 <200 nM, and are each ≥50-fold less immunosuppressive than cyclosporin A.