کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1371644 981849 2010 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
3-Urea-1-(phenylmethyl)-pyridones as novel, potent, and selective EP3 receptor antagonists
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
3-Urea-1-(phenylmethyl)-pyridones as novel, potent, and selective EP3 receptor antagonists
چکیده انگلیسی

A series of 3-urea-1-(phenylmethyl)-pyridones was discovered as novel EP3 antagonists via high-throughput screening and subsequent optimization. The synthesis, structure–activity relationships, and optimization of the initial hit that resulted in potent and selective EP3 receptor antagonists such as 11g are described.

A series of 3-urea-1-(phenylmethyl)-pyridones was discovered as novel EP3 antagonists via high-throughput screening and subsequent optimization. The synthesis, structure–activity relationships, and optimization of the initial hit that resulted in potent and selective EP3 receptor antagonists such as 11g are described.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 20, Issue 22, 15 November 2010, Pages 6744–6747
نویسندگان
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