کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1371729 | 981853 | 2010 | 4 صفحه PDF | دانلود رایگان |
A series of copper(II) and zinc complexes of 2-hydroxyacetophenone semicarbazones have been prepared and evaluated as superoxide dismutase (SOD) mimetics. The SOD-like activity of parent ligands and complexes were determined by the inhibition of nitroblue tetrazolium (NBT) reduction method, using xanthine/xanthine oxidase as the superoxide radical generator. The obtained results indicate that Cu(II) complexes exhibited the most potent SOD-like activities with the IC50 values ranging from ca. 0.2 to 4 μM. Among copper complexes, 2-hydroxy-4-methoxyacetophenone semicarbazone analog was the most active compounds (IC50 ≈0.2 μM).
A series of copper(II) and zinc complexes of 2-hydroxyacetophenone semicarbazones have been prepared and evaluated as superoxide dismutase (SOD) mimetics.Figure optionsDownload as PowerPoint slide
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 20, Issue 10, 15 May 2010, Pages 3070–3073