کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1371777 981856 2012 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
[11C]GSK2126458 and [18F]GSK2126458, the first radiosynthesis of new potential PET agents for imaging of PI3K and mTOR in cancers
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
[11C]GSK2126458 and [18F]GSK2126458, the first radiosynthesis of new potential PET agents for imaging of PI3K and mTOR in cancers
چکیده انگلیسی

GSK2126458 is a highly potent inhibitor of phosphoinositide 3-kinase (PI3K) and mammalian target of rapamycin (mTOR) with low picomolar to subnanomolar activity. [11C]GSK2126458 and [18F]GSK2126458, new potential PET agents for imaging of PI3K and mTOR in cancer, were first designed and synthesized in 40–50% and 20–30% decay corrected radiochemical yield, and 370–740 and 37–222 GBq/μmol specific activity at end of bombardment (EOB), respectively.

Radiosynthesis of [11C]GSK2126458 and [18F]GSK2126458, new potential PET agents for imaging of PI3K and mTOR in cancer, is first reported.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 22, Issue 4, 15 February 2012, Pages 1569–1574
نویسندگان
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