کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1371802 981856 2012 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Optimization of phenylacetic acid derivatives for balanced CRTH2 and DP dual antagonists
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Optimization of phenylacetic acid derivatives for balanced CRTH2 and DP dual antagonists
چکیده انگلیسی

Our first generation CRTH2 and DP dual antagonists, represented by AMG 009, are more potent toward the CRTH2 receptor than to the DP receptor. Here we report our efforts in the discovery of CRTH2 and DP dual antagonists with more balanced potencies to both receptors, such as compound 15.

Our first generation CRTH2 and DP dual antagonists, represented by AMG 009, are more potent toward the CRTH2 receptor than to the DP receptor. Here we report our efforts in the discovery of CRTH2 and DP dual antagonists with more balanced potencies to both receptors, such as compound 15.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 22, Issue 4, 15 February 2012, Pages 1686–1689
نویسندگان
, , , , , , , , , , , , , , , , ,