A direct synthesis of 5,6-dihydroindolo[2,1-a]isoquinolines that exhibit immunosuppressive activity

Dihydroindolo[2,1-a]isoquinolines were synthesized from tetrahydroisoquinolines and α-fluoroaldehydes by a novel two-step procedure. These compounds exhibited significant immunosuppressive activity against IL-2, IL-10 and IFN-γ.

Dihydroindolo[2,1-a]isoquinolines were synthesized from tetrahydroisoquinolines and α-fluoroaldehydes by a novel two-step procedure. These compounds exhibited significant immunosuppressive activity against IL-2, IL-10 and IFN-γ.Figure optionsDownload as PowerPoint slide