Synthesis and SAR of 1,4,5,6-tetrahydropyridazines as potent cannabinoid CB1 receptor antagonists

The synthesis and structure–activity relationship studies of 1,4,5,6-tetrahydropyridazines are described. The target compounds 3–5 represent a novel class of potent and selective CB1 receptor antagonists.

Tetrahydropyridazines represent a novel class of potent CB1 receptor antagonists.Figure optionsDownload as PowerPoint slide