کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1371888 | 981857 | 2009 | 4 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Synthesis of 1,6,7,8-tetrahydro-naphtho[2,3-d]-azepino[4,5-b]indole-9,14-diones and their inhibitory effects on pro-inflammatory cytokines Synthesis of 1,6,7,8-tetrahydro-naphtho[2,3-d]-azepino[4,5-b]indole-9,14-diones and their inhibitory effects on pro-inflammatory cytokines](/preview/png/1371888.png)
A rapid route to a series of naphthoquinone-fused indole derivatives via irradiation in a modified commercial domestic microwave is reported. The desired products were produced in high yields and short reaction times. The naphthoquinone-fused indole derivatives were evaluated for their pro-inflammatory cytokines responses using lipopolysaccharide (LPS)-stimulated RAW264.7 murine macrophages. The results showed that most of the tested compounds inhibit the production of nitric oxide (NO), prostaglandin (PG)E2, tumour necrosis factor (TNF)-α, interleukin (IL)-6 and IL-1β in RAW264.7 cells treated with LPS.
The synthesis and inhibitory effects on pro-inflammatory cytokines of 1,5,6,7,8,14b-hexahydro-naphtho[2,3-d]-azepino[4,5-b]indole-9,14-diones are reported.Figure optionsDownload as PowerPoint slide
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 19, Issue 19, 1 October 2009, Pages 5753–5756