کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1371990 981863 2009 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Efficient synthesis of (±)-parasitenone, a novel inhibitor of NF-κB
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Efficient synthesis of (±)-parasitenone, a novel inhibitor of NF-κB
چکیده انگلیسی

Dehydroxymethylepoxyquinomicin (DHMEQ, 1) is a novel nuclear factor-κB (NF-κB) inhibitor that inhibits DNA binding of NF-κB components including p65. To inspect its biological activity of 1, we synthesized parasitenone (3), possessing the common epoxycyclohexenone moiety of 1. Assessment of the inhibitory activity against NF-κB indicated that the epoxycyclohexenone moiety is the most essential element for the NF-κB inhibitory activity and the salicylic acid moiety may contribute the binding efficiency and specificity.

Parasitenon (2) was synthesized and the inhibitory activity against NF-κB was assessed.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 19, Issue 18, 15 September 2009, Pages 5383–5386
نویسندگان
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