کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1371993 981863 2009 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis of 2α-substituted-14-epi-previtamin D3 and its genomic activity
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Synthesis of 2α-substituted-14-epi-previtamin D3 and its genomic activity
چکیده انگلیسی

We synthesized and isolated 2α-substituted analogs of 14-epi-previtamin D3 after thermal isomerization at 80 °C for the first time. The VDR binding affinity and transactivation activity of osteocalcin promoter in HOS cells were evaluated, and the 2α-methyl-substituted analog was found to have greater genomic activity than 14-epi-previtamin D3.

2α-Substituted analogs of 14-epi-previtamin D3 showed greater genomic activity than 14-epi-previtamin D3 such as the VDR binding affinity and transactivation activity of osteocalcin promoter in HOS cells.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 19, Issue 18, 15 September 2009, Pages 5397–5400
نویسندگان
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