کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1372066 981865 2010 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Novel semisynthetic spin-labeled derivatives of podophyllotoxin with cytotoxic and antioxidative activity
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Novel semisynthetic spin-labeled derivatives of podophyllotoxin with cytotoxic and antioxidative activity
چکیده انگلیسی

A series of novel spin-labeled podophyllotoxin derivatives were synthesized by reacting the corresponding N-(1-oxyl-2,2,6,6-tetramethyl-4-piperidinyloxy carbonyl)-amino acids with 4β-amino-4′-demethylepipodophyllotoxin. The synthesized derivatives 12a–g were evaluated for the partition coefficients, cytotoxicities in vitro against three tumor cell lines (A-549, HL-60, and RPMI-8226) and antioxidative activities in tissues of SD rats by the TBA method. The vast majority of target compounds have shown superior or comparable activities against A-549, HL-60, and RPMI-8226 compared to VP-16, and they have shown more significant antioxidative activities and superior water solubility than VP-16.

The synthesized compounds showed superior or comparable cytotoxicities and pronounced antioxidative activity compared to VP-16.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 20, Issue 3, 1 February 2010, Pages 983–986
نویسندگان
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