کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1372081 981865 2010 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Solubilization and deaggregation of cobalt bis(dicarbollide) derivatives in water by biocompatible excipients
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Solubilization and deaggregation of cobalt bis(dicarbollide) derivatives in water by biocompatible excipients
چکیده انگلیسی

In the field of medicinal chemistry, cobalt bis(dicarbollide) derivatives are promising therapeutic agents. The potential pharmaceutical utilization of metallacarboranes is complicated due to spontaneous self-assembling in water. This problem can be solved by using suitable deaggregating agent. We present here the comprehensive screen of substituted cobalt bis(dicarbollide) derivatives with cyclodextrin derivatives, classical surfactants and amphiphilic copolymers to find general biocompatible excipients. Preliminary results are obtained by using UV/Vis spectroscopy as the technique with the best ratio of applicable information to time and source dependence.

Scheme of cobalt bis(dicarbollide) derivative 2 and DIMEB.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 20, Issue 3, 1 February 2010, Pages 1045–1048
نویسندگان
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