Molecular design of small organic molecules based on structural information for a conformationally constrained peptide that binds to G-CSF receptor

Based on structural information for a peptide (P8-2KAQ) that binds to granulocyte-colony stimulating factor receptor (G-CSFR), small ligands with a biaryl scaffold were designed and their binding affinities were evaluated.

The synthesis of ligand 4 binds to G-CSF receptor is reported.Figure optionsDownload as PowerPoint slide