کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1372110 | 981865 | 2010 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Molecular design of small organic molecules based on structural information for a conformationally constrained peptide that binds to G-CSF receptor
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Molecular design of small organic molecules based on structural information for a conformationally constrained peptide that binds to G-CSF receptor Molecular design of small organic molecules based on structural information for a conformationally constrained peptide that binds to G-CSF receptor](/preview/png/1372110.png)
چکیده انگلیسی
Based on structural information for a peptide (P8-2KAQ) that binds to granulocyte-colony stimulating factor receptor (G-CSFR), small ligands with a biaryl scaffold were designed and their binding affinities were evaluated.
The synthesis of ligand 4 binds to G-CSF receptor is reported.Figure optionsDownload as PowerPoint slide
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 20, Issue 3, 1 February 2010, Pages 1169–1172
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 20, Issue 3, 1 February 2010, Pages 1169–1172
نویسندگان
Radwan El-Haggar, Ken Kamikawa, Kazuya Machi, Zhengmao Ye, Yuko Ishino, Takeshi Tsumuraya, Ikuo Fujii,