کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1372155 981866 2011 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A small molecule that preferentially binds the closed conformation of Hsp90
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
A small molecule that preferentially binds the closed conformation of Hsp90
چکیده انگلیسی

Described is the synthesis of three different fluorescein-tagged derivatives of a macrocycle, and their binding affinity to heat shock protein 90 (Hsp90). Using fluorescence polarization anisotropy, we report the binding affinity of these fluorescein-labeled compounds to Hsp90 in its open state and ATP-dependent closed state. We show that the compounds demonstrate a conformation-dependent preference for binding to the closed state.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 21, Issue 23, 1 December 2011, Pages 7068–7071
نویسندگان
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