کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1372163 981866 2011 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Biological evaluation of glucose and deoxyglucose derivatives radiolabeled with [99mTc(CO)3(H2O)3]+ core as potential melanoma imaging agents
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Biological evaluation of glucose and deoxyglucose derivatives radiolabeled with [99mTc(CO)3(H2O)3]+ core as potential melanoma imaging agents
چکیده انگلیسی

Glucose 9 and 2-deoxyglucose 10 were successfully synthesized and radiolabeled with [99mTc(CO)3(H20)3]+ intermediate in high yield. The complexes were characterized by HPLC and its stability with histidine over time was challenged. Cell uptake and biodistribution studies in melanoma-bearing C57BL/6 mice were performed. Both compounds showed accumulation in tumor tissue with high tumor-to-muscle ratios. Thus, d-glucose- and d-2-deoxyglucose-99mTc complex could be considered as agents for melanoma diagnosis.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 21, Issue 23, 1 December 2011, Pages 7102–7106
نویسندگان
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