کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1372226 | 981867 | 2009 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Semisynthesis and antiproliferative evaluation of a series of 3′-aminoflavones
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Semisynthesis and antiproliferative evaluation of a series of 3′-aminoflavones Semisynthesis and antiproliferative evaluation of a series of 3′-aminoflavones](/preview/png/1372226.png)
چکیده انگلیسی
A series of 3′-aminoflavones 5,6,7,8-tetra- or 5,7-dioxygenated on the A-ring was synthesized from tangeretin or naringin, two natural Citrus flavonoids. These flavones were evaluated for antiproliferative activity, activation of apoptosis, and inhibition of tubulin assembly. The most antiproliferative flavones exhibit a common 5-hydroxy-6,7,8-trimethoxy substitution pattern on the A-ring.
A series of 3′-aminoflavones 5,6,7,8-tetra or 5,7-dioxygenated on the A-ring was synthesized from tangeretin or naringin, two natural Citrus flavonoids, then evaluated for their antiproliferative and proapoptotic activities, and for the inhibition of tubulin assembly.Figure optionsDownload as PowerPoint slide
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 19, Issue 13, 1 July 2009, Pages 3502–3506
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 19, Issue 13, 1 July 2009, Pages 3502–3506
نویسندگان
Jérôme Quintin, Didier Buisson, Sylviane Thoret, Thierry Cresteil, Guy Lewin,