کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1372431 981870 2010 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
In vitro and in vivo anti-Leishmania activity of polysubstituted synthetic chalcones
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
In vitro and in vivo anti-Leishmania activity of polysubstituted synthetic chalcones
چکیده انگلیسی

The in vitro screening of 43 polysubstituted chalcones against Leishmania amazonensis axenic amastigotes, led to the evaluation of 9 of them in a macrophage-infected model with the two other most infectious Leishmania species prevalent in Peru (L. braziliensis and L. peruviana). The five most active and selective chalcones were studied in vivo, resulting on the identification of two chalcones with high reduction parasite burden percentages.

The in vitro screening of 43 polysubstituted chalcones against Leishmania amazonensis axenic amastigotes, lead to the evaluation of nine of them in a macrophage-infected model with the two other most infectious Leishmania species prevalent in Peru (Leishmania braziliensis and Leishmania peruviana), five of the most active and selective were studied in vivo, resulting on the identification of two chalcones with high reduction parasite burden percentages.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 20, Issue 1, 1 January 2010, Pages 100–103
نویسندگان
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