Discovery of diphenylmethane analogs as anti-bovine diarrhea viral agents

Based on antiviral screening of our diphenylmethane derivatives prepared as steroid substitutes, we identified a 1,1-diphenylcyclobutane analog (9) and two diethyldiphenylsilane analogs (12 and 13) as superior lead compounds with potent anti-bovine viral diarrhea virus (BVDV) activity, having 50% effective concentration (EC50: based on reduction of BVDV replication-induced cell destruction) and 50% cytotoxic concentration (CC50: based on reduction of viable cell number) values of 6.2–8.4 μM and >100 μM, respectively, in Madin–Darby bovine kidney (MDBK) cells infected with BVDV.

1,1-Diphenylcyclobutane analog and diethyldiphenylsilane analogs have been identified as superior lead compounds with potent anti-bovine viral diarrhea activity.Figure optionsDownload as PowerPoint slide