کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1372626 981872 2009 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis and peptide incorporation of an unnatural amino acid containing activity-based probe for protein tyrosine phosphatases
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Synthesis and peptide incorporation of an unnatural amino acid containing activity-based probe for protein tyrosine phosphatases
چکیده انگلیسی

An unnatural amino acid was synthesized to incorporate a quinone methide-generating activity-based probe for protein tyrosine phosphatases (PTPs) and then integrated into a PTP1B-specific substrate. The resulting probe led to preferential labeling of PTP1B in cell lysates in the presence of PTP4A3.

The synthesis, peptide incorporation and potential application of an unnatural amino acid containing activity-based probe for protein tyrosine phosphatases are reported.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 19, Issue 12, 15 June 2009, Pages 3264–3267
نویسندگان
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