The discovery of novel calcium sensing receptor negative allosteric modulators

The design and profile of a series of zwitterionic calcium sensing receptor negative allosteric modulators is described. Evaluation of key analogues using a rat model demonstrate a robust response, significantly improved potency over ronacaleret and have the potential as an oral, anabolic treatment for osteoporosis.

The discovery of a structurally novel, orally bioavailable series of calcium sensing receptor negative allosteric modulators is described.Figure optionsDownload as PowerPoint slide