Novel BK channel openers containing dehydroabietic acid skeleton: Structure–activity relationship for peripheral substituents on ring C

A series of dehydroabietic acid (DHAA, 2) derivatives was synthesized and evaluated as BK channel openers in an assay system of CHO-K1 cells expressing hBKα channels. Systematic modifications of the peripheral functionality of ring C of DHAA showed that the introduction of a nitro or (thio)urea group in ring C greatly enhanced the BK channel-opening activity.

A series of dehydroabietic acid derivatives was synthesized and evaluated as BK channel openers in an assay system of CHO-K1 cells expressing hBKα channels.Figure optionsDownload as PowerPoint slide