Methoxy-substituted 9-aminomethyl-9,10-dihydroanthracene (AMDA) derivatives exhibit differential binding affinities at the 5-HT2A receptor

The synthesis and 5-HT2A receptor affinities of a series of methoxy-substituted 9-aminomethyl-9,10-dihydroanthracene (AMDA) derivatives are reported. Molecular modeling techniques are used to elucidate probable binding modes for the compounds.