کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1372744 | 981879 | 2009 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Solid-phase synthesis of a library based on biphenyl-containing trypsin-like serine protease inhibitors
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The solid-phase synthesis of a library based on an unusual biphenyl-containing trypsin-like serine protease inhibitor is described. Key to this effort was the synthesis of a highly functionalized aryl boronic acid reagent which required the development of a novel and efficient method to convert a triflate to a pinacolboronate in large scale.
A novel and efficient method for synthesizing a highly functionalized aryl boronic acid reagent in large scale was developed. A hug biphenyl scaffold library for trypsin-like serine protease inhibitor by solid-phase synthesis is described.Figure optionsDownload as PowerPoint slide
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 19, Issue 22, 15 November 2009, Pages 6477–6480
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 19, Issue 22, 15 November 2009, Pages 6477–6480
نویسندگان
Shuhao Shi, Shirong Zhu, Samuel W. Gerritz, Bogumila Rachwal, Zheming Ruan, Robert Hutchins, Ramesh Kakarla, Michael J. Sofia, James Sutton, Daniel Cheney,