کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1372785 981881 2011 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Aryl 1,4-diazepane compounds as potent and selective CB2 agonists: Optimization of drug-like properties and target independent parameters
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Aryl 1,4-diazepane compounds as potent and selective CB2 agonists: Optimization of drug-like properties and target independent parameters
چکیده انگلیسی

A high throughput screening campaign identified aryl 1,4-diazepane compounds as potent and selective cannabinoid receptor 2 agonists as compared to cannabinoid receptor 1. This class of compounds suffered from poor drug-like parameters as well as low microsomal stability and poor solubility. Structure–activity relationships are described with a focus on improving the drug-like parameters resulting in compounds with improved solubility and permeability.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 21, Issue 14, 15 July 2011, Pages 4276–4280
نویسندگان
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