Pyrimidine-based antagonists of h-MCH-R1 derived from ATC0175: In vitro profiling and in vivo evaluation

A series of pyrimidine analogues derived from ATC0175 were potent antagonists of human MCH-R1 in vitro with improved receptor selectivity. One example was shown to inhibit food intake and decrease body weight in a chronic study. However observed effect was most likely not due to interaction with the MCH-R1.