کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1372916 | 981886 | 2011 | 5 صفحه PDF | دانلود رایگان |

A series of steroid–polyamine conjugates were synthesized and evaluated for their antimicrobial activity. This study was focused on the effect of stereochemistry at the C-3 and C-5 of steroids and types of polyamine at C-3 on activity against various human pathogens. All the conjugates exhibited strong antimicrobial activities against Gram-positive strains. Compound 18 was found to be the most potent in these series with a MIC value as low as 1 μg/mL against the bacterium Staphylococcus aureus ATCC6538P.
A series of steroid–polyamine conjugates were synthesized and evaluated for their antimicrobial activity. The 3β-sperminyl-23,24-bisnor-5β-cholane (18) was the most potent in this series with a MIC value as low as 1 μg/mL against Staphylococcus aureus ATCC6538P.Figure optionsDownload as PowerPoint slide
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 21, Issue 13, 1 July 2011, Pages 3861–3865