کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1372916 981886 2011 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A concise synthesis and antimicrobial activities of 3-polyamino-23,24-bisnorcholanes as steroid–polyamine conjugates
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
A concise synthesis and antimicrobial activities of 3-polyamino-23,24-bisnorcholanes as steroid–polyamine conjugates
چکیده انگلیسی

A series of steroid–polyamine conjugates were synthesized and evaluated for their antimicrobial activity. This study was focused on the effect of stereochemistry at the C-3 and C-5 of steroids and types of polyamine at C-3 on activity against various human pathogens. All the conjugates exhibited strong antimicrobial activities against Gram-positive strains. Compound 18 was found to be the most potent in these series with a MIC value as low as 1 μg/mL against the bacterium Staphylococcus aureus ATCC6538P.

A series of steroid–polyamine conjugates were synthesized and evaluated for their antimicrobial activity. The 3β-sperminyl-23,24-bisnor-5β-cholane (18) was the most potent in this series with a MIC value as low as 1 μg/mL against Staphylococcus aureus ATCC6538P.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 21, Issue 13, 1 July 2011, Pages 3861–3865
نویسندگان
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