Efficient synthesis, structural characterization and anti-microbial activity of chiral aryl boronate esters of 1,2-O-isopropylidene-α-d-xylofuranose

A simple and efficient synthetic approach toward a series of chiral aryl boronate esters, starting from d-xylose, as anti-microbial agents, is described herein. Minimum inhibitory concentration and zone of inhibition revealed that these derivatives exhibit potent anti-bacterial and anti-fungal properties. Herein, we report the first anti-microbial activity of this class of compounds. All products have been characterized by NMR (1H, 13C and 11B), IR, elemental and mass spectral study.

A simple and efficient synthetic approach toward a series of chiral aryl boronate esters of 1,2-O-isopropylidene-α-d-xylofuranose, as anti-microbial agents, is described herein. Minimum inhibitory concentration and zone of inhibition revealed that these derivatives exhibit potent anti-bacterial and anti-fungal properties. Herein, we report the first anti-microbial activity of this class of compounds.Figure optionsDownload as PowerPoint slide